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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T14175 | Aldose reductase-IN-1 | AT-001,Caficrestat | Others , Reductase |
Aldose reductase-IN-1 (AT-001) is a aldose reductase inhibitor (IC50: 28.9 pM). | |||
T16910 | Sorbinil | Reductase | |
Sorbinil is an Aldose reductase inhibitor. Sorbinil plays a therapeutic role in treating diabetes and diabetic complications decreases AR activity and inhibit the polyol pathway. | |||
T22757 | EBPC | Reductase | |
EBPC is an inhibitor of aldose reductase. | |||
T23403 | Sulindac sulfone | Reductase , COX | |
Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. | |||
T10393 | AT-007 | Reductase | |
AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats. | |||
T2013 | Ponalrestat | Reductase | |
Ponalrestat is an aldose reductase inhibitor. | |||
T35317 | Zopolrestat | CP 73850,CP73850,CP-73850,Zopolrestatum | Reductase |
Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM). | |||
T17114 | Tolrestat | AY-27773 | Reductase |
Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM). | |||
T5195 | Alrestatin | AY-22284 | Reductase |
Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro. | |||
T61555 | Aldose reductase-IN-6 | ||
Aldose reductase-IN-6 (Compound 3) is a competitive inhibitor of aldose reductase (AR), possessing an IC50 of 3.164 μM and a Ki of 0.018 μM. Notably, Aldose reductase-IN-6 demonstrates no cytotoxicity toward normal cells... | |||
T60897 | Aldose reductase-IN-5 | ||
Aldose reductase-IN-5 is an inhibitor of aldose reductase (ALR2) that enhances the combination of inhibitory excitability and antioxidant capacity, thereby delaying the diabetes complications progress. | |||
T62951 | Aldose reductase-IN-2 | ||
Aldose reductase-IN-2 (Compound 5f) is a potent inhibitor of aldose reductase (AR) with antioxidant properties. aldose reductase-IN-2 is a promising anti-diabetic complication drug. | |||
T61957 | Aldose reductase-IN-3 | ||
Aldose reductase-IN-3 (Compound 5) is an effective and moderately selective aldose reductase (AR) inhibitor (IC50=3.99 μ M). Aldose reductase is a molecular target involved in various inflammatory diseases (including sep... | |||
T60601 | Aldose reductase-IN-4 | ||
Aldose reductase-IN-4 (compund IIc) is an inhibitor of aldose reductase with IC50s of 11.70 μM and 0.98 μM for ALR1 and ALR2, respectively [1]. | |||
T1458 | Epalrestat | ONO2235 | Reductase |
Epalrestat (ONO2235), an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particul... | |||
T15568 | Imirestat | Alcon 1576,AL 1576,HOE 843 | Reductase |
Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research. | |||
T33389 | Minalrestat | ARI509,WAY-121509,WAY121509,WAYARI-509,ARI-509,WAY-ARI-509 | Reductase |
Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients. | |||
T27583 | IDD388 | IDD-388,IDD 388 | DNA/RNA Synthesis |
IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor. | |||
T7478 | 2-Chloro-1-(4-fluorobenzyl)benzimidazole | Reductase | |
2-Chloro-1-(4-fluorobenzyl)benzimidazole is an inhibitor of aldose reductase (ALR2). | |||
T16756 | Risarestat | CT 112 | Reductase |
Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia. | |||
T15756 | Lidorestat | IDD-676 | Reductase |
Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat... | |||
T67805 | Oxepinac | ||
oxepinac is an effective and well-tolerated compound for the treatment of painful osteoarthritis. oxepinac has no teratogenic effect on mouse and rabbit fetuses in animal experiments. | |||
T15281 | Fidarestat | SNK 860 | Reductase |
Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease. | |||
T16723 | Ranirestat | AS-3201 | Others |
Ranirestat effective and orally active aldose reductase inhibitor ( IC50s: 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively and a Ki: 0.38 nM for recombinant human AR). Ranirestat has a neuroprotect... | |||
T25019 | AL 4114 | Al4114,AL-4114 | |
AL 4114 is used as an aldose reductase inhibitor. | |||
T5195L | Alrestatin Sodium | AY 22284A,AY-22284A,Alrestatine sodium,AY22284A | |
Alrestatin is a specific inhibitor of the aldose reductase enzyme. | |||
T71868 | Cemtirestat | ||
Cemtirestat is an aldose reductase inhibitor | |||
T68630 | M 79175 | ||
M 79175 is an aldose reductase inhibitor. | |||
T68651 | ICI-105552 | ||
ICI-105552 is an aldose reductase inhibitor. | |||
T71052 | M 16287 | ||
M 16287 is a potent aldose reductase inhibitor. | |||
T70579 | SX 3202 | ||
SX 3202 is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy. | |||
T70968 | ICI-222155 | ||
ICI-222155 is an aldose reductase inhibitor. | |||
T27362 | FR 62765 | FR62765,FR-62765 | |
FR 62765 is a derivative of WF-3681, an aldose reductase inhibitor. | |||
T31075 | CP-744809 | UNII-U63F8E95J1,CP 744809,ARI-809 | |
CP-744809 is a highly selective oral small-molecule aldose reductase inhibitor. | |||
T35299 | Zenarestat | CI1014,FR74366,FK-366,CI-1014,FR 74366,FR-74366 | |
Zenarestat (CI-1014, FK-366, FR-74366) is an aldose reductase inhibitor being studied as a treatment for diabetic neuropathy and cataracts. | |||
T71057 | WF 2421 | ||
WF 2421 is an aldose reductase inhibitor produced by Humicola grisea. | |||
T68929 | Lidorestat monohydrate | ||
Lidorestat monohydrate is an aldose reductase inhibitor potentially for the treatment of diabetic neuropathy and diabetic complications. | |||
T70679 | Spr 210 | ||
Spr 210 is an aldose reductase (AR) inhibitor with potential uses as a therapeutic agent for preventing and improving some diabetic complications. | |||
T79005 | 6-Hydroxyluteolin | ||
6-Hydroxyluteolin (Compound 17), a flavonoid, exhibits inhibition of aldose reductase (AR) [1]. | |||
T62456 | ALR1/2-IN-1 | ||
ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) (IC50: 3.26 μM) and aldose reductase (ALR2) (IC50: 3.06 μM) inhibitor with anticancer effects. | |||
T73305 | ALR2-IN-3 | ||
ALR2-IN-2, a potent aldose reductase (ALR2) inhibitor, demonstrates IC50 values of 22 nM for rat ALR2 and 116 nM for ALR1, respectively. This compound is utilized in diabetic complications research. | |||
T73304 | ALR2-IN-2 | ||
ALR2-IN-2, a potent aldose reductase (ALR2) inhibitor, exhibits IC50 values of 27 nM for rat ALR2 and 228 nM for ALR1, respectively. This compound is utilized in the research of diabetic complications. | |||
T78612 | APPA | Apoptosis | |
APPA, an aldose reductase inhibitor, demonstrates efficacy in preventing apoptosis and symptoms of Streptozotocin-induced diabetes in rats through inhibition of the polyol pathway. This compound shows promise for researc... | |||
T13037 | Sulindac sulfide | cis-Sulindac sulfide | Raf , Others , AChR |
Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibito... | |||
T78702 | PTP1B/AKR1B1-IN-1 | Phosphatase | |
PTP1B/AKR1B1-IN-1 is a dual inhibitor targeting protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), exhibiting inhibitory potency with IC50s of 0.06 μM for PTP1B and 4.3 μM for AKR1B1. Additionally, it... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6S2384 | Poliumoside | Reductase | |
Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibitory effects on rat lens aldose reductase w... | |||
T5S1131 | Ganoderic acid C6 | Others | |
1. Ganoderic acid C6 has antinociceptive activity. | |||
T0725 | Isoliquiritigenin | ISL,Isoliquiritigen,GU17 | Apoptosis , Influenza Virus , Reductase , Autophagy |
Isoliquiritigenin (ISL), an anti-tumor flavonoid from the root of Glycyrrhiza glabra, suppresses aldose reductase (IC50=320 nM). | |||
T3801 | (Rac)-Byakangelicin | Bjacangelicin,Bjakangelicin,Biacangelicin,7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-,Byakangelicin | Others |
(Rac)-Byakangelicin (7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-) is an antineoplastic agent. | |||
TN1661 | Ganoderic acid C2 | Reductase , Histamine Receptor , Immunology/Inflammation related | |
Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen. | |||
T10183 | 6-Methoxytricin | Reductase | |
6-Methoxytricin is a flavonoid isolated from Artemisia absinthium.6-Methoxytricin is an inhibitor of aldose reductase (AR) (IC50s: 30.29 μM) and inhibits AKT activity.6-Methoxytricin has anti-inflammatory activity and in... | |||
TN1975 | Neosmitilbin | Neoastilbin | Others |
Neosmitilbin (Neoastilbin) may have antioxidant and anti-inflammatory activities, it shows potent inhibition of lens aldose reductase. | |||
TN1656 | Ganoderenic acid A | Others | |
Ganoderenic acid A has a potent hepatoprotective, and cytotoxic effects, it shows inhibitory activity on human aldose reductase in vitro. | |||
T5S1026 | Apigenin-7-glucuronide | Apigenin 7-O-glucuronide | MMP |
Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 1... | |||
T6S0840 | Engeletin | Dihydrokaempferol 3-rhamnoside | NF-κB , Reductase |
1. Engeletin (Dihydrokaempferol 3-rhamnoside) may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engeletin inhibits a recombinant ... | |||
T3665 | Tectoridin | Shekanin | Estrogen Receptor/ERR , Reductase |
Tectoridin (Shekanin) possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflammatory and hypoglycemic activities; Tectoridin an... | |||
TN2122 | Quercetin 3-gentiobioside | Quercetin-3-gentiobioside | Reductase |
Quercetin 3-gentiobioside (Quercetin-3-gentiobioside) is an inhibitor of AR and AGE formation and can be extracted from A. iwayomogi.Quercetin 3-gentiobioside inhibits the biological activity of aldose reductase (AR) and... | |||
TN1037 | Groenlandicine | Topoisomerase | |
Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR). Groenlandicine selectively ... | |||
T5S1988 | Isorhamnetin-3-O-glucoside | Isorhamnetin-3-O-beta-D-Glucoside | Others |
Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.... | |||
T5813 | BYAKANGELICIN | Reductase | |
BYAKANGELICIN,a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor,and is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lea... | |||
T6102 | 2'-acetylacteoside | Antioxidant , Reductase | |
2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-Acetylacteoside shows antiproliferative effects on aortic smoo... | |||
T2S1635 | 3-Isomangostin | MTH1 | |
3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has free radical scavenging activity; it shows antiplasmodial ac... | |||
TL0008 | Gigantol | Wnt/beta-catenin , Glucosidase | |
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a... | |||
T4918 | DL-Glyceraldehyde | Glyceric aldehyde | Reductase |
DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, ... | |||
TN5183 | Triptocalline A | Others | |
Triptocalline A shows an inhibitory effect on rat lens aldose reductase. | |||
T39435 | Myrciacetin | ||
Myrciacetin, a flavonoid derived from Rhododendron dauricum, exhibits inhibitory activity against rat lens aldose reductase, as demonstrated by an IC50 value of 13 μM. | |||
TN3287 | 8-Lavandulylkaempferol | Reductase , AChR | |
8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, respectively. It shows inhibitory activities against aldose re... | |||
TN5672 | Puerol A | ||
Puerol A exhibits potent inhibitory effects on aldose reductase with IC50 values of 6.4 uM. dl-Puerol A has antioxdiant activity, it shows inhibitory effects on copper ion-induced protein oxidative modification of mouse ... | |||
TN6645 | Lucidumol A | ||
Lucidumol A has relatively good effect against aldose reductase with IC50 of 19.1uM. Lucidumol A has cytotoxic activity, it reduced cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependen... | |||
T75627 | Ganoderic acid Df | ||
Ganoderic acid Df, a lanostane-type triterpenoid isolated from the fruiting body of Ganoderma lucidum, potently inhibits aldose reductase with an IC 50 of 22.8 ± 0.6 μM [1]. | |||
TMA0291 | Dehydroglyasperin D | GSK-3 , p38 MAPK , ROS , Akt , COX , PI3K , DNA/RNA Synthesis , Prostaglandin Receptor , JNK | |
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction wit... | |||
TN3760 | Danshenol A | Reductase | |
Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A also has antitumor activity in T-24, QGY, K562, Me180 and B... | |||
TN3692 | Conduritol A | TNF | |
Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function; it also can markedly preve... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02438 | AKR1B1 Protein, Human, Recombinant (His) | Human | E. coli |
Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest... | |||
TMPJ-00524 | SORD Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Sorbitol dehydrogenase, also known as L-iditol 2-dehydrogenase and SORD, is a member of the zinc-containing alcohol dehydrogenase family. SORD exsits in a homotetramer and binds one zinc ion per subunit. SORD is expresse... |